Recently I've been working with Substance Designer to create solid pipeline on getting hi-res sculpts from ZBrush into base for shaders in V-Ray. Substance is very much like visual scripting, so at first might be intimidating, but once you get the grasp of its logic it becomes just fun to work with. Above a quick test of how Substance can be used in combination with V-Ray. All maps were generated in Substance - I started with just two meshes from ZBrush, hi- and lo-res. From mesh projection I got Normals, AO and Curvature and from those I generated all dirt masks, distortion and additional bump.
I hope I will manage to find enough time to record video explaining the Substance -> VRay workflow. At the moment I'm trying to finish one big project, but hopefully in upcoming weeks I will get a while to do a demonstration.
Please let me know if you have any questions or want to hear more. Leave a comment or drop me an e-mail and I will try to answer your questions.